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Significance levels were set at 5% (two-sided) with no adjustment for multiplicity
The experiment was divided into a normal control group, a DSS model group, and a DSS+IGF-1 LR3 treatment group (with doses of 0.1mg/kg, 0.5mg/kg, and 1mg/kg, respectively, orally administered daily), and treated continuously for 7 days
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W., Gerencser, A
Zepbound is initiated at 2.5 mg once weekly (an initiation dose, not a maintenance dose), with gradual increases every four weeks to minimize gastrointestinal side effects
or fatigability in adulthood (34, 35)
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