The safety profile is consistent with known oncology indications
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Colorectal Cancer Awareness Starts Here Colorectal cancer remains a significant health challenge, but awareness of symptoms and risk factors can lead to earlier detection and better survival rates
The polyol pathway, where excess glucose is converted to sorbitol and fructose by the enzyme aldose reductase, further exacerbates oxidative stress by depleting NADPH, a crucial cofactor for the regeneration of reduced glutathione (GSH) [180]
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Rajpoot K, Jain SK (2019) Irinotecan hydrochloride trihydrate loaded folic acid-tailored solid lipid nanoparticles for targeting colorectal cancer, development, characterization, and in vitro cytotoxicity study using HT-29 cells