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[26] Another randomized, double-blinded, placebo-controlled trial was conducted in 54 adults which administered oral glutathione for six months, either in a dose of 250 mg or 1000 mg per day

At week 4, women in the treatment group displayed improved skin elasticity (+12.7%), reduced wrinkle volume (16.5%), decreased transepidermal water loss (10.8%), increased hydration (+3.5%), and enhanced collagen density compared with baseline values (measured via specialized skin analysis instrumentation)

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ERS activation, in turn, stimulates excessive ROS production (171)

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