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2022 Mar 5;63:102195
Safety profile in PIONEER trials: Nausea: 11% to 20% (dose-dependent) Diarrhea: 8% to 11% Vomiting: 5% to 9% Discontinuation due to GI side effects: 4% to 7% The side effect rates are lower than injectable semaglutide at weight-loss doses, likely because the systemic exposure is lower
The jump from 5mg to 10mg, on the other hand, is enormous, a leap from 16% to 21.4% average body weight reduction
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[] This shift underscores a broader focus on CV and renal protection, weight management, and overall risk reduction in T2D management
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