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The primary metabolite of the lipoxygenase, 15-HPETE, reacts with the enzyme further to yield the 14,15epoxide, designated eoxin A 4 , and then by analogy with leukotriene biosynthesis, this in turn is conjugated with glutathione to produce eoxin C 4 and thence eoxin D 4 (linked to Cys-Glc) and eoxin E 4 (linked to Cys only)