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Given the current evidence gaps, incretin-based medications should not be considered established lipedema treatments

Monitor for mental health changes, including depression or suicidal thoughts, and contact a provider if symptoms occur

Inject the bacteriostatic water slowly down the wall, allowing it to run down and wet the powder gradually from the side rather than hitting it with direct force

Karhunen LJ, Juvonen KR, Huotari A, Purhonen AK, Herzig KH

Injection Site Reactions : As semaglutide is administered via subcutaneous injection, some individuals may experience mild discomfort, redness, or swelling at the injection site

Key takeaways Changes to menstrual cycles are not listed as specific side effects in the prescribing information for tirzepatide