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Understanding GLP-1 Medications GLP-1 receptor agonists (GLP-1s) are a class of medication originally developed to help people with Type 2 diabetes manage their blood sugar levels
The design of novel therapeutic agents such as monoclonal antibodies (mAbs), stem cells and genes is currently under way and clinical trials have been attempted, however, the therapeutic efficacy has been greatly limited by the fact that large molecular agents cannot penetrate the blood-brain barrier (BBB)
Importantly, the FDA labeling cautions against using semaglutide in patients with severe gastrointestinal disease, including severe gastroparesis
S2CID 29816004
The GI Learning Curve: Why Your Gut is Reacting to GLP-1s To better understand why GLP-1 stomach discomfort (among other side effects) happens, its helpful to know how these medications work
Haste and Stress Magnify Discomfort A typical human pattern I see is that sudden, intense hunger leads to fast, uncomfortable eating that triggers nausea
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