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Weekly injections of MEDI4166 reduced body weight in a dose-dependent manner (Fig
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The combination of these two receptors is what separated tirzepatide from earlier single-agonist medications like semaglutide
![Structures of (a) GLP-1, (b) GIP and (c) tirzepatide [19, 88, 90]](https://www.researchgate.net/publication/370926483/figure/fig4/AS:11431281185432337@1693619320519/Structures-of-a-GLP-1-b-GIP-and-c-tirzepatide-19-88-90-Amino-acids-are.png)
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