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For example, in pancreatic cancer, the inflammasome component NLRP4 mediates PARPi resistance by promoting NOXO1 expression, which inhibits nuclear translocation of SIRT7, thereby enhancing ROS-induced autophagy and reactivating DDR via reduced H2AX accumulation and impaired BRCA1RAD51 complex formation

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Let it trickle down the glass wall toward the powder rather than jetting directly onto the lyophilized material

This success proved the efficacy of the FcRn blockade and validated FcRn as a clinical target for treatment of IgG-mediated autoimmune diseases

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In: Bhawan J, Gonzalez-Serva A, eds