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At 32 weeks, participants treated with ecnoglutide 2.4 mg once weekly achieved a mean weight reduction of 13.2%, compared to an increase of 0.1% in the placebo group
PMCID: PMC4020673.
This contraindication exists because MTC arises from the same C-cells that showed tumor formation in rodent studies, and individuals with MTC history may have underlying genetic susceptibility that could theoretically interact with GLP-1 receptor stimulation
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