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S., Kahn, C
Cardiovascular Risk Markers TRIUMPH-4 also assessed a panel of cardiometabolic biomarkers, and the results were broadly favorable across the board: Non-HDL cholesterol significant reductions, indicating improved atherogenic lipid burden Triglycerides meaningful decreases, consistent with the known effects of GLP-1 and GIP receptor activation on lipid metabolism High-sensitivity C-reactive protein (hsCRP) substantial reductions, reflecting decreased systemic inflammation
It also lists pregnancy, type 1 diabetes, and a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia type 2 as contraindications on the semaglutide side
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