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Some conditions make it harder for the body to absorb vitamin B12, so the treatment might need to be adjusted
The New England Journal of Medicine, 326 (6), 368374
Selection should be guided by your provider based on clinical efficacy expectations, cost tolerance, supply reliability needs, and whether you have insurance coverage
Cardiovascular outcomes (e.g., SELECT and SOUL trials), 2
Symptoms range from mild upper-right abdominal discomfort to severe pain that needs urgent care
When dose escalation to 12.5mg or 15mg is appropriate If you have been at 10mg for 12 or more weeks, have optimized nutrition and activity, and have confirmed a genuine plateau (no weight change for 8 or more consecutive weeks despite adherence), then escalation to 12.5mg may be warranted
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