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B12 Deficiency and Dermatological Symptoms Patients with a vitamin B12 deficiency may notice dermatological symptoms such as hyperpigmentation, vitiligo, or dry, irritated skin
Current evidence suggests that high-dose B12 supplementation can trigger acne in susceptible people by altering skin bacteria behaviour, though this does not affect everyone
Women and men with absorption disorders also cant properly absorb and process it
There is no standard clinical guidance for cycling the stack because human trial data is minimal
(Frontiers in Nutrition, 2026 review)
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