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To examine whether activation of LS GLP-1R neurons is sufficient to suppress food intake independent of endogenous GLP-1R or exogenous liraglutide, we injected an AAV into the dLS of GLP-1R-ires-Cre mice expressing the excitatory Gq-coupled designer receptor exclusively activated by designer drugs (DREADD) hM3D-mCherry in a Cre-dependent fashion (43)

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For weight management: BMI of 30 or greater (obesity), OR BMI of 27 or greater with at least one weight-related comorbidity (hypertension, type 2 diabetes, dyslipidemia, obstructive sleep apnea) For type 2 diabetes: Diagnosis of type 2 diabetes Inadequate glycemic control on current therapy Understanding how to qualify for GLP-1 medications helps navigate the process

At the time of writing this article, Tirzepatide is only approved in the treatment of Type 2 Diabetes but is in late-stage trials for obesity and is expected to be approved by the end of 2023