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Wiviott SD, Raz I, Bonaca MP, et al
The reduction in metabolic rate that occurs during prolonged caloric deficit, resulting in fewer calories burned at rest than predicted for a given body weight
Consistent with our findings in cells, UBQLN2 was detected in LBs in the substantia nigra of four sporadic PD patients
It was originally reported after isolation from rabbit blood, but its precise endogenous precursor and physiological role remain unresolved
The gradual escalation protocol (2mg, 4mg, 8mg, 12mg over 12 weeks) was optimized in clinical trials to balance effectiveness with tolerability
The Journal of Clinical Endocrinology & Metabolism , 70 (4), 975982
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