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The restraints for the N-terminal lipid modification of Cagri were generated by the electronic Ligand Builder and Optimization Workbench (eLBOW) in PHENIX
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These findings emphasize that targeted antagonism of NMDA receptor signalling lowers body weight independently of MC4R, indicating that this preclinical drug candidate might not only be effective in treating polygenic obesity but also holds potential as an effective weight loss strategy for patients with loss-of-function mutations in MC4R , the most common form of monogenic obesity 32
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Improved Exercise Endurance: By helping your body use fat as fuel more efficiently, you can exercise longer without running out of energy as quickly
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