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Semaglutide works by enhancing insulin secretion, suppressing glucagon, slowing gastric emptying, and reducing appetite through central pathways
This lower appetite can be helpful if overeating was a major struggle before
Ann NY Acad Sci 652 : 487489
It fundamentally changes what this class of drugs can achieve
A reduction in the activity of such an enzyme means GLP-1 stays active longer, which extends satiety signals and insulin modulating effects
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