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The general tolerability profile observed across the phase 2 program is that of the incretin class: predominantly gastrointestinal adverse effects nausea, vomiting, diarrhea, constipation that are usually dose-related and most prominent during dose escalation

2022 Jan 11;115(1):310

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Berberine can lower blood glucose and may potentiate the effects of diabetes medications, including metformin, sulfonylureas, and insulin, potentially causing hypoglycaemia

TB-500 has been developed to leverage the benefits of thymosin beta-4, focusing on enhancing tissue regeneration, reducing inflammation, and promoting overall recovery