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Genetics influence how quickly collagen degrades and how efficiently the body produces new structural proteins

Anthracycline-based FAC and FEC regimens demonstrate Level 1 evidence through Phase III trials, with GEICAM showing superior disease-free survival in 985 women and EBCTCG meta-analyses confirming 38% mortality reduction in women under 50 years, establishing it as adjuvant standard despite manageable cardiotoxicity

Ethics declarations Ethics approval All experimental procedures were performed in accordance with international guidelines for the care and use of laboratory animals, including the ARRIVE guidelines, and were consistent with national regulations

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