by 2025, more than 30 million Americans were taking them for weight Eli Lillys triple agonist, retatrutide, demonstrated an average weight loss of 16.8% in a Phase 3 trial for the treatment of type 2 diabetes, the company announced today
However, it is not a magic weight-loss pill
Similarly, tirzepatide has shown even more impressive results, with some studies indicating weight loss of up to 20% in participants
Mitochondrial implication in apoptosis
Contraindications to GLP-1 receptor agonists include personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, and severe gastroparesis
In my lifetime, I have not seen anything revolutionize diabetes (and certainly obesity) care in the way GLP-1 receptor agonists have in the last few years