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Diabetologia 55 , 24562468 (2012)
Importantly, these benefits were observed across all subgroups analyzed, irrespective of gender or age (33)
The mechanism seems to be independent of the catalytic activity, since these effects were not mimicked by systemic DPP-4 inhibition (73, 82), and it was suggested that soluble DPP-4 interacted with caveolin-1 on adipose tissue macrophages, the down-stream effects of which combined with actions of other pro-inflammatory molecules such as factor Xa, to lead to activation of the inflammatory signaling pathway (83) (Figure 3)
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The potential cognitive and neurogenesis enhancing effects of GLP-analogs may be an additional benefit for using GLP-1R agonists as a treatment for AUD
Presented at: AUA 2023, Chicago, Illinois, April 28-May 1
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