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In addition, there are several other stress kinases that were found to regulate NRF2 nuclear localization by phosphorylation, including the ER stress kinase PERK and the energy sensor AMPK [13, 14]
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While these tyrosinase inhibitors are frequently used in whitening products, studies have highlighted significant side effects (Pillaiyar et al., 2017)
The regulatory pathway is different from commercial drug approval, but it is not unregulated
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