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Pharmacological treatments Despite two decades of clinical trials, no pharmacotherapy had been approved for MASLD and MASH until 2024, when the Food and Drug Administration (FDA) approved Rezdiffra (resmetirom) for noncirrhotic MASH with moderate to advanced fibrosis

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The medication continues providing metabolic benefits and some appetite suppression even when subjective hunger levels increase slightly

Demonstrates clinically meaningful body weight reduction independent of glycaemic effects

By increasing the time it takes for food to leave the body, it also slows digestion

Approximately one-third achieved 20% or greater weight loss