Since then, more potent GLP-1 and dual agonists (targeting both GLP-1 and GIP) have been approved, including for weight loss in those living with obesity
Alzheimers & Dementia, 17 , e057848
The diagnostic approach can vary depending on the nature of an individuals symptoms and the resources available
Consistent, gradual weight loss like 30 lbs over nine months is typically a strong response to these medications if combined with diet and lifestyle tweaks
Dose adjustments may be needed with changes in physical activity, changes in meal patterns (i.e., macronutrient content or timing of food intake), changes in renal or hepatic function or during acute illness to minimize the risk of hypoglycemia or hyperglycemia [see Warnings and Precautions (5.3)]
Addition of exenatide or sitagliptin to insulin in new onset type 1 diabetes: a randomized, open label study