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It is noteworthy that systemic adverse drug reactions need further investigation if ripasudil is used systemically, as it rarely enters systemic circulation through the blood-ocular barrier when administered as eye drops in current clinical trials (Table 1 and 2
Diversos ensayos clnicos han evaluado estos suplementos como coadyuvantes , mostrando resultados alentadores en la reduccin del dolor, la fatiga, el insomnio y los trastornos cognitivos
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Mutations causing the loss of these sites may adversely affect MT-associated proteins and the interaction of these proteins with Shank3 [293]
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