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You just have to know when youre working from robust human data, versus extrapolating from mouse models

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Mammals usually rely solely on extracellular uptake as the primary source of Cys, but some mammals also use cystathionine -lyase (CGL)-mediated cystathionine-cleavage in the transsulfuration pathway as a surrogate Cys source if System X c is blocked (Shimada and Stockwell, 2016)

In preclinical models this raises intracellular NAD and SAM, lowers 1-methylnicotinamide, and suppresses fat-cell lipogenesis, which is the proposed basis for the weight and adiposity reductions seen in obese mice