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For the co-primary endpoint of percentage change in body weight from baseline to week 48, power was determined using a predicted placebo effect of 3% and a survodutide effect of 10% (assumed in a mixed population 1:1 ratio with and without T2D

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However, the timing and extent of these effects vary according to the persons health, starting weight, treatment response, eating habits, and physical activity

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The duration of action may shorten