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Thus, these data suggest that late-life targeting of IGF-1R signaling can recapitulate effects observed in genetic models of constitutive IGF-1R haploinsufficiency on lifespan
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Effects of liraglutide in hypothalamic arcuate nucleus of obese mice
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The SELECT trial, published in the New England Journal of Medicine in 2023, demonstrated that semaglutide significantly reduced major adverse cardiovascular events in patients with established cardiovascular disease and overweight or obesity, representing a landmark finding for GLP-1 receptor agonists in cardiovascular risk reduction
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