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With respect to the prescription of semaglutide for ensuring weight management, Health Canada has given approval to the 2.4 mg of injection to serve as a measure to be implemented in addition to a reduced calorie diet and increased activity to manage weight in patients having: A BMI of 30 kg/m2 or higher (obesity) A BMI of 27 kg/m2 or higher (overweight) In addition to this, it is also expected that the patient should suffer from chronic weight-related issues, like dyslipidemia, hypertension, or obstructive sleep apnea

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Because natural GLP-1 is rapidly broken down by DPP-4 in one to two minutes, it would need to be either administered continuously, or researchers would need to produce a mimic with improved stability that would last longer in the bloodstream

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