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Individual response to the medication can also vary greatly

Hormonal IUDs can lighten or stop periods, while the non-hormonal (copper) IUD is hormone-free but may cause heavier periods for some (16)

Gastrointestinal side effects are the most common concern: semaglutide can cause nausea, vomiting, and diarrhea, while metformin independently causes diarrhea and abdominal discomfort in up to 30% of users

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Patients taking the medication should watch for symptoms like unexplained shortness of breath, chest pain, fainting, or leg swelling and seek immediate medical attention if they arise

doi: 10.1053/j.gastro.2009.09.004 127 WidenmaierSBKimSJYangGKDe Los ReyesTNianCAsadiAet al