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Appetite suppression continues as therapeutic effect while unpleasant side effects fade
Clinical trials show tirzepatide (dual GLP-1/GIP agonist) produces greater average weight loss than semaglutide (GLP-1 only), but individual responses vary substantially
This is some of the best-documented peptide discontinuation data available, with exact biomarker numbers attached
Current recommendations from the American Society of Anesthesiologists (ASA) suggest withholding GLP-1 agonists one week prior to the procedure for those on weekly dosing and withholding GLP-1 agonists on the day of the procedure (American Society of Anesthesiologists 2024)
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