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A paracrine relationship exists between GLP-1-secreting L cells and somatostatin-secreting D-cells (Jepsen et al., 2019)

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Moreover, International Diabetes Federation in 2024 provided a data according to which by 2050, projections show that 1 in 8 adults, approximately 853 million, will be living with diabetes, an increase of 46% and over 90% of people with diabetes have type 2 diabetes