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Elevated levels of inflammatory cytokines, growth- and angiogenic factors have toxic effects on sperm, oocytes, embryonal development, gamete transportation, and implantation

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Moderate activity has been demonstrated in the ciliary body, lens epithelial cells, and the retina, but none has been detected in the vitreous body

This finding is consistent with other reports 41 demonstrating UA-induced increases in autophagy and reduction in alpha-synuclein accumulation

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