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This is not typically recommended, as clinical trials used once-weekly dosing

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At 80 weeks, all doses of retatrutide (4 mg, 9 mg, and 12 mg) met the primary and key secondary endpoints for obesity, delivering clinically meaningful weight loss

In FLOW, semaglutide, a GLP-1 RA, reduced the risk of major kidney outcomes, MACE and all-cause mortality in people with T2D and CKD, regardless of baseline mineralocorticoid receptor antagonist use