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The role of reactive oxygen species in severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection-induced cell death
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Martinez JL, Zammit MD, West NR, Christian BT, Bhattacharyya A (2021) Basal Forebrain Cholinergic Neurons: Linking Down Syndrome and Alzheimers Disease
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Consistent with the proposed direct-to-DNA mechanism, published in vitro work has documented that testagen specifically penetrates into the cell nucleus and interacts with DNA in a sequence-selective manner: in FITC-labelled studies in HeLa cells, testagen entered the nucleus and bound preferentially to CAG-containing oligodeoxyribonucleotide sequences, consistent with the model that these ultrashort peptides can engage DNA directly and thereby influence gene expression epigenetically [1]
In both cellular and animal models, Epitalon shows promise in enhancing neuroplasticity, maintaining cholinergic tone, and reducing oxidative DNA damage, all hallmarks of both healthy brain aging and resistance to cognitive decline
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