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It would also need a plan for monitoring side effects and stopping criteria
& Siroosbakht, S
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443 These agents exert their anti-atherosclerotic effects through various mechanisms, including by improving blood lipid profiles, 444 preserving endothelial integrity and regulating endothelial function, 445 as well as modulating inflammatory processes
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A box was constructed to fully enclose the small molecule and protein by adjusting the Grid Box parameters, followed by running AutoGrid 4, setting the docking parameters and algorithms, running AutoDock4, and exporting the results file in PDBQT format
One aliquot was used for enzymatic activity assays following post-mitochondrial fraction isolation (centrifugation for 20 min at 10,000 g at 4 C)
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