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Retatrutide for type 2 diabetes: Phase 2 trial results (36-week study, HbA1c reductions, weight loss) New England Journal of Medicine (2023) Jastreboff AM, et al

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Or is it most prudent to test first

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Am J Epidemiol

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The 15 g dose is not lethal, the 18 g dose is marginally lethal, and the 30 g dose is definitely lethal without N-acetyl cysteine (NAC) rescue in the ER

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While the loss of GSH does not cause liver failure, it decreases lipogenic enzyme expression, circulating triglyceride levels, and fat stores

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