blindness and glp 1 GLP-1 Agonists—commonly used for weight loss diabetes—are now being linked to serious eye health concerns, including an increased risk of a condition called NAION, which can cause irreversible blindness. With GLP-1 Lipsitz, Ponterio & Comerford |

Thus, substitution of (replacing rather than adding) an agent with cardiorenal benefit might be appropriate if people are at or near A1c target

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In the cholesterol biosynthesis pathway, expression of genes such as lanosterol synthase ( Lss ), cytochrome P450, family 51 ( Cyp51 ), NAD(P) dependent steroid dehydrogenase-like ( Nsdhl ) and 7-dehydrocholesterol reductase ( Dhcr7 ) were decreased

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The article describes the discomfort as typically mild and transient, resolving as the body equilibrates, and notes that persistent aches instead warrant a look at dehydration, nutrient shortfalls, or an unrelated musculoskeletal condition