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These changes arent just because of age
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69 Thirdly, during the DPN, excess saturated fatty acids (SFAs) and hyperglycemia depolarize mitochondrial membranes and generate ROS, 70 which eventually produce mitochondrial dysfunction and Schwann cells (SCs) apoptosis
doi:10.1016/j.micinf.2009.08.007 279
Some affected metabolites link to amino acid metabolism and changes in key pathways such as amino acid metabolism has been observed (184, 187, 408, 409)
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