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doi: 10.1042/CS20110374 37 DarsaliaV.HuaS.LarssonM.MallardC.NathansonD.NystromT.et al
The pool of reduced glutathione (GSH) is fueled by glutathione reductase (GR) activity, which catalyzes the reduction of glutathione disulfide (GSSG) to two molecules of GSH by electron transfer from NADPH
The amino acid is liberated upon degradation of the g-Glu-amino acid by the enzyme g-glutamyl cyclotransferase, which generates 5-oxoproline instead of glutamate
Researchers found that glutathione levels in the blood increased by up to 40% after just two weeks of daily supplementation
In the five in vitro studies, although a decrease in the apoptosis rate of granulosa cells was observed at specific doses, it was not confirmed whether this effect could translate into an improvement in oocyte quality in vivo (Fabov et al., 2023
Additionally, due to its newness, long-term data is still being gathered
