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In cohort 1, pancreatic islets were isolated and subjected to perifusion at basal glucose levels (2.8 mmol/L) followed by perifusion with media containing stimulatory glucose concentration (16.7 mmol/l) to induce an insulin secretory response
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The long half-life and slow absorption and elimination rates mean it lingers in your system, so you don't need more frequent doses to keep it around and effective
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