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They combine studies with different drugs, durations, populations, designs, and follow-up conditions
Manufacturing is done at an FDA registered facility which complies with NSF and GMP guidelines
This case reflects a typical response timeline for combination therapies, especially when initiated early
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Another limitation is extremely low bioavailability: Most polyphenols suffer from poor oral absorption, strong first-pass metabolism, and insufficient brain concentrations (for instance, curcumin reaches less than 1% of plasma levels in the brain)
Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial
