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Disturbances of AMP-packaging into granules and alterations in the granule exocytosis pathway manifest as disorganized and reduced numbers of cytoplasmic granules as well as a diffuse cytoplasmic lysozyme expression (8) ( Figure 5F, scheme )

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Figure 6: Photograph of Sir Frederick Banting and Charles Best with dog 408 taken in August 1921 by Henry Mahon on the roof of the University of Torontos Medical Building

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