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Significant Weight Reduction: Semaglutide has been proven to induce substantial weight loss in individuals who struggle with obesity
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| Insulin resistance markers | As much as 50% less | 24 to 48 weeks | No major cardiac events | Triglyceride reduction | Large, correlated with liver fat | 24 to 48 weeks | Weight Loss Retatrutide resulted in significant weight loss in multiple clinical trials
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Some patients, like Jane, have their prescriptions blocked by insurers, scared away by its price tag, through tools like prior authorization (requiring tasks like seeing a specialist in obesity medicine first, or undertaking a weight management program for months before a GLP-1 receptor agonist is on the table)
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2 The microbiota-gut-brain axis The microbiota-gut-brain axis (MGBA) is defined as the ensemble of bidirectional interactions between the gut, its microbiota, and the brain (Figure 1
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