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In DESTINY-Lung02 trial, grade 3 AEs occurred in 38.6% and 58% of patients with 5.4 and 6.4 mg/kg, respectively
The peptide is naturally occurring, non-toxic, and effective at very low concentrations
It never had that impact
Genetic variation in GLP-1 receptor expression and glucose-dependent insulinotropic peptide (GIPR) signaling can influence how effectively a given dose engages these pathways
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