As of November 2025, nearly 80% (77.8%) of all Microdose GLP-1Rx users stayed engaged with the Noom app for 4 or more weeks, and D30 engagement for our December cohort was over 40% (43.6%), 1 which is at least 10 times higher than average health, medical, and fitness app retention
Additionally, Melanotan II has been investigated for its ability to reduce food intake and body weight, as well as its effects on thermogenesis in mice
10.1038/nm.4345 126 WuL.ZhouB.Oshiro-RapleyN.LiM.PauloJ
Injectable forms provide higher bioavailability and more consistent results, while oral forms offer convenience but reduced efficiency
It was developed as a highly selective agonist of the growth hormone secretagogue receptor (GHS-R1a, also known as the ghrelin receptor)
For researchers who want access now, purchasing retatrutide through the research peptide market is possible but requires careful attention to sourcing, purity testing, and proper handling