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In addition, satiety signals from the liver and gastrointestinal tract signal through the vagus nerve to the nucleus of the solitary tract (NTS, for the Latin term nucleus tractus solitarii ) to cause meal termination, and in combination with the hypothalamus, integrate the various signals to determine the feeding response

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studies show users who stop therapy regain 50% of lost weight within a year, while those who maintain treatment preserve most gains

The UK Chief Medical Officers recommend at least 150 minutes of moderate-intensity activity per week for adults, which also supports weight management and glycaemic control