Author contributions ZH: Conceptualization, Methodology, Software, Validation, Visualization, Writing original draft, Writing review and editing
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DEM (420 mm, 0.25 ml) in oil was administered intrarectally and colonic tissue examined over time (1, 4 and 24 hours) for GSH levels and injury
HO-1 is anticipated to serve as a novel target for addressing diabetic complications, and it holds promise as a potential therapeutic agent for diabetes and its associated complications
Although the exact mechanisms by which the coordinated actions of GLP-1 receptor agonism and NMDA receptor antagonism correct metabolic diseases await further elucidation, the extensive alterations in transcriptomic and proteomic responses within the hypothalamus, linked to glutamatergic signalling and synaptic plasticity, imply that the conjugate might elicit neurostructural changes in GLP-1-receptor-expressing neurons
F1000Res, doi: 10.12688/f1000research.11775.1.