These results represent significant clinical benefit, but they also reveal important variability: roughly 20-30% of participants achieved weight loss below 5%, while others exceeded 15% reduction
Treatments were blinded to the investigators, and mice were monitored for clinical abnormalities ( Supplemental Table 6 )
The experiments were performed on adult (6 months old, 220250 g) and old (2224 months old, 350450 g) male Wistar rats
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