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This raises the intriguing possibility of harnessing such pathways to durably "re-educate" and restore core functional pathways of dysfunctional immune cells like Tregs." Pingchang Yang, co-senior author of the new LSA study Using human Tregs taken from allergic asthmatic patients, Li's team confirmed that these cells not only showed the hallmarks of senescence but also demonstrated a profound loss of two key Treg proteins, the master transcription factor FOXP3 and the immune signaling molecule IL-10
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